Guangming Zhou, Professor, vice dean, IAA Academician

Academic History:

B.S. in Biochemistry, Lanzhou University

Ph.D. in Particle Physics and Nuclear Physics, Institute of Modern Physics, Chinese Academy of Sciences

Post-Doc., Brookhaven National Laboratory, Dept. of Biology

Post-Doc., Columbia University, Center of Radiation Research

Professor, Soochow University, SKLRMP, 2018 to date

Research Interests:

Tumorigenesis of ionizing radiation

Regulatory functions of radiation-inducible non-coding RNAs

Development of countermeasures against space radiation

Development of novel techniques for tumor therapy with particle radiation

Research Experience and Accomplishments:

2015.05 to date School of Radiation Medicine and Protection, Soochow University, Professor

2008.11-2009.01National Institute of Radiological Research, Japan, senior visiting scholar

2007.03-2015.05Institute of Modern Physics, Chinese Academy of Sciences, Professor, Director of Department of Space Radiobiology

2002.10-2003.11School of Radiology of Chiba University, visiting scholar; National Institute of Radiological Research, Japan, collaborative researcher

1994.06-2002.10 Institute of Modern Physics, Chinese Academy of Sciences, Assistant Professor

Academic Awards and Honors:

2008, Hundred Talent of Chinese Academy of Sciences

2019, IAA Academician

Main Publications:

1、Zhou G. (2020) Mechanisms underlying FLASH radiotherapy, a novel way to enlarge the differential responses to ionizing radiation between normal and
tumor tissues. Radiation Medicine and Protection, 1: 35-40

2、胡文涛，周光明*。中国空间辐射生物研究面临的挑战和机遇。科学通报，2019，64（36）：3824-3829

3、Hu W, Zhu L, Pei W, Pan S, Wang Z, Wu A, Pei H, Nie J, Li B, Furusawa Y, Konishi T, Hei TK*, Zhou G*. (2019) Overexpression of Ras-Related C3 Botulinum Toxin Substrate 2 Radiosensitizes Melanoma Cells In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity, 1-10

4、Mao W#, Guo Z#, Dai Y#, Nie J, Li B, Pei H*, Zhou G*. (2019) LNC CRYBG3 inhibits tumor growth by inducing M phase arrest. J Cancer, 10:2764-2770

5、Guo Z, Pei H, Nie J, Hu W, Zhang J, Ding J, Pan S, Li B, Hei TK, Chen W*, Zhou G*. (2019) Anti-cancer effects of CQBTO, a chloroquine, and benzo(e)triazine oxide conjugate. Chem Biol Drug Des, 1-9

6、Pei W, Hu W, Chai Z, Zhou G*. (2019) Current status of space radiobiological studies in China. Life Sciences in Space Research, 22: 1-7

7、Zhang J, Zheng L, Wang Z, Pei H, Hu W, Nie J, Shang P, Li B, Hei TK, Zhou G*. (2019) Lowering iron level protects against bone loss in focally irradiated and contralateral femurs through distinct mechanisms. Bone120:50-60.

8、Hu W, WeicW, Zhu L, Yin D, Wei A, Bi X, Liu T, Zhou G, Qiang Y, Sun X, Wen Z*, Pan P*. (2019) Enhancing proliferation and migration of fibroblast cells by electric stimulation based on triboelectric nanogenerator, Nano Energy, 57: 600-607

9、Pei H, Hu W, Guo Z, Chen H, Ma J, Mao W, Li B, Wang A, Wan J, Zhang J, Nie J,Zhou G*, Hei TK*.(2018) Long non-coding RNA CRYBG3 blocks cytokinesis by directly binding G-actin. Cancer Res. 78:4563-4572.

10、Chen H, Pei H, Hu W, Ma J, Zhang J, Mao W, Nie J, Xu C, Li B, Hei TK, Wang C, Zhou G*. (2018) Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by interacting with lactage dehydrogenase A. J. Cancer9:2580-2588.

11、Hu W, Pei H, Sun F, Li P, Nie J, Li B, Hei TK,Zhou G*. (2018) Epithelial mesenchymal transition in non-targeted lung tissues of Kunming mice exposed to X-rays is suppressed by celecoxib. J. Radiat. Res. 59(5):583-587.

12、Hu W, Pei W, Zhu L, Nie J, Pei H, Zhang J, Li B, Hei TK, Zhou G*. (2018) Microarray Profiling of TGF-β1-Induced Long Non-Coding RNA Expression Patterns in Human Lung Bronchial Epithelial BEAS-2B Cells. Cell Physiol Biochem. 50(6):2071-2085.

13、Pei H, Guo Z, Wang Z, Dai Y, Zheng L, Zhu L, Zhang J, Hu W, Nie J, Mao W, Jia X, Li B, Hei TK, Zhou G*. (2018) RAC2 promotes abnormal proliferation of quiescent cells by enhanced JUNB expression via the MAL-SRF pathway. Cell Cycle 17:1115-1123.

14、Zhang J, Wang Z, Wu A, Nie J, Pei H, Hu W, Wang B, Shang P, Li B, Zhou G*. (2017) Differences in responses to X-ray exposure between osteoclast and osteolast cells. J Radiat Res, 58(6): 791-802

15、Song L, Ye W, Cui Y, Lu J, Zhang Y, Ding N, Hu W, Pei H, Yue Z*, Zhou G*.  (2017) Ecto-5'-nucleotidase (CD73) is a biomarker for clear cell renal carcinoma stem-like cells. Oncotarget, 8(19): 31977-31992

16、Pei H, Zhang J, Nie J#, Ding N, Hu W, Hua J, Hirayama R, Furusawa Y, Liu C, Li B, Hei TK, Zhou G*. (2017) RAC2-P38 MAPK-dependent NADPH oxidase activity is associated with the resistance of quiescent cells to ionizing radiation. Cell Cycle, 16(1):113-122

17、Hu W, Xu S, Yao B, Hong M, Wu X, Pei H, Chang L, Ding N, Gao X, Ye, C, Wang J, Hei TK and Zhou G*. (2014) MiR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode. RNA Biology, 11(9): 1189-1198

18、Pei H, Chen W, Hu W, Zhu M, Liu T, Wang J and Zhou G*. GANRA-5 protects both cultured cells and mice from various radiation types by functioning as a free radical scavenger. Free Radical Research, 48(6): 670-678 (2014)

19、Zhang H, Sun Z, Wei W, Liu Z, Fleming J, Zhang J, Lin N, Wang M, Chen M, Xu Y, Zhou J, Li C*, Bi L*, Zhou G*. Identification of serum microRNA biomarkers for tuberculosis using RNA-seq. PLoS ONE, 9(2): e88909 (2014).

20、Hu W, Pei H, Ding N, He J, Wang J, Furusawa Y, Hirayama R, Matsumoto Y, Liu C, Kawata T, Zhou G*. Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures. Journal of Radiation Research, 55(1): 10-16 (2014).

21、Wang J, He J, Su F, Ding N, Hu W, Yao B, Wang W, and Zhou G*. Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition. Cell Death and Disease, 4: e699 (2013)

22、Ye C, Zhang X, Wan J, Chang L, Bing Z, Zhang S, Li J, He J, Wang J*, Zhou G*. Long-term G2-arrested cells exposed to ionizing radiation undergo cellular senescence via slipping into the G1 phase. Cell Cycle, 12(9): 1424-1432 (2013)

23、Wang F, Bing Z, Zhang Y, Ao B, Zhang S, Ye C, He J, Ding N, Ye W, Xiong J, Sun J, Furusawa Y, Zhou G*, and Yang L. Quantitative proteomic analysis for radiation-induced cell cycle suspension in 92-1 melanoma cell line. Journal of Radiation Research, 1-14 (2013)

24、Chang L, Hu W, Ye C, Yao B, Song L, Wu X, Ding N, Wang J, and Zhou G*. miR-3928 activates ATR pathway by targeting dicer. RNA Biology, 9(10): 1247-1254 (2012)

25、He J, Li J, Ye C, Zhou L, Zhu J, Wang J, Mizota A, Furusawa Y, and Zhou G*. Cell cycle suspension: A novel process lurking in G2 arrest. Cell Cycle, 10(9): 1468-1476 (2011)

26、Wang J, Su F, Smilenov LB, Zhou L, Hu W, Ding N, and Zhou G*. Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity. Radiation Oncology, 6:96 (2011)

27、Ding N, Wu X, He J, Chang L, Hu W, Li W, Wang J, Wang T, and Zhou G*. Detection of Novel Human MiRNAs Responding to X-ray Irradiation. Journal of Radiation Research, 52, 425-432 (2011)

28、Zhou G, Smilenov LB, Lieberman HB, Ludwig T, Hall EJ. Radiosensitivity to high energy iron ions is influenced by heterozygosity for ATM, RAD9 and BRCA1. Advances in Space Research, 46: 681-686 (2010)

29、Zhou G, Bennett PV, Cutter NC, and Sutherland BM. Proton-HZE-particle sequential dual-beam exposures increase anchorage-independent growth frequencies in primary human fibroblasts. Radiation Research, 166(3): 488-94 (2006)

30、Zhou G, Kawata T, Furusawa Y, et al. Protective effects of melatonin against low- and high-LET irradiation. Journal of Radiation Research, 47(2): 175-181 (2006)

Contact:

Phone: 86-512-65884829

Email:gmzhou@suda.edu.cn

Fax: 86-512-65884830