陈冬，特聘副教授，硕士生导师

电子邮箱：chendong@suda.edu.cn

通讯地址：苏州工业园区仁爱路199号，邮编215123

个人简历：

陈冬，现为苏州大学放射医学与防护学院双聘教授，唐仲英血液学研究中心特聘教授，博士生导师，入选国家高层次人才青年项目，姑苏创新创业领军人才计划。2010年获得中国科学技术大学神经生物学博士学位。2015-2020于美国埃默里大学（EMORY UNIVERSITY）从事博士后研究，2021年加入苏州大学唐仲英血液学研究中心。长期从事肿瘤的转化医学研究与临床前期研究领域，专注于代谢重编程与白血病等肿瘤发生发展的关系，在Cancer Discovery、Molecular Cell、Cell Chemical Biology等杂志共计发表高质量研究论文14余篇。

研究方向：

1.肿瘤细胞代谢通路的“重编程”与“重布线”的机制

2.代谢物作为信号分子参与调控肿瘤信号通路的机制

3.癌基因在肿瘤生长过程中所需要的特殊“肿瘤代谢物”及其相关机制：

4.肿瘤特异性代谢“重编程”与放疗抵抗的机制

代表性论著：

1.Chen, D.; Gao, F.; Li, B.; Wang, H.; Xu, Y.;Zhu, C.; Wang, G., Parkin mono- ubiquitinates Bcl-2 and regulates autophagy.J Biol Chem2010,285 (49),38214-23.

2.Li, B.; Hu, Q.; Xu, R.; Ren, H.; Fei, E.; Chen, D.; Wang, G., Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence. BMC Cell Biol2012,13,20.

3.Hu, Q.; Li, B.; Xu, R.; Chen, D.; Mu, C.; Fei, E.; Wang, G., The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation. Sci Signal 2012,5 (238), ra61.

4.Gao, F.; Chen, D.; Hu, Q.; Wang, G., Rotenone directly induces BV2 cell activation via the p38 MAPK pathway. PLoS One 2013,8 (8),e72046.

5.Zhou, L.; Wang, H. F.; Ren, H. G.; Chen, D.; Gao, F.; Hu, Q. S.; Fu, C.; Xu, R. J.; Ying, Z.; Wang, G. H., Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. Acta Pharmacol Sin2013,34 (5),651-6.

6.Yu, Y. X.; Li, Y. P.; Gao, F.; Hu, Q. S.; Zhang, Y.; Chen, D^#.; Wang, G. H^#., VitaminK2 suppresses rotenone-induced microglial activation in vitro. Acta Pharmacol Sin2016,37 (9), 1178-89.

7.Fan, J.; Lin, R.; Xia, S.; Chen, D.; Elf, S. E.; Liu, S.; Pan, Y.; Xu, H.; Qian, Z.; Wang, M.; Shan, C.; Zhou, L.; Lei, Q. Y.; Li, Y.; Mao, H.; Lee, B. H.; Sudderth, J.; DeBerardinis, R. J.; Zhang, G.; Owonikoko, T.; Gaddh, M.; Arellano, M. L.; Khoury, H. J.; Khuri, F. R.; Kang, S.; Doetsch, P. W.; Lonial, S.; Boggon, T. J.; Curran, W. J.; Chen, J., Tetrameric Acetyl- CoA Acetyltransferase 1 Is Important for Tumor Growth. Mol Cell 2016,64 (5), 859- 874.

8.Lin, R.; Xia, S.; Shan, C.; Chen, D.; Liu, Y.; Gao, X.; Wang, M.; Kang, H. B.; Pan, Y.; Liu, S.; Chung, Y. R.; Abdel-Wahab, O.; Merghoub, T.; Rossi, M.; Kudchadkar, R. R.; Lawson, D. H.; Khuri, F. R.; Lonial, S.; Chen, J., The Dietary Supplement Chondroitin- 4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells. Mol Cell2018,69 (6), 923-937 e8.

9.Chen, D.; Li, Y. P.; Yu, Y. X.; Zhou, T.; Liu, C.; Fei, E. K.; Gao, F.; Mu, C. C.; Ren, H. G.; Wang, G. H., Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells. Acta Pharmacol Sin2018,39 (4),597-606.

10.Chen, D.; Xia, S.; Wang, M.; Lin, R.; Li, Y.; Mao, H.; Aguiar, M.; Famulare, C. A.;Shih, A. H.; Brennan, C. W.; Gao, X.; Pan, Y.; Liu, S.; Fan, J.; Jin, L.; Song, L.; Zhou, A.; Mukherjee, J.; Pieper, R. O.; Mishra, A.; Peng, J.; Arellano, M.; Blum, W. G.; Lonial, S.;Boggon, T. J.; Levine, R. L.; Chen, J., Mutant and Wild-Type Isocitrate  Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer. Cancer Discov 2019,9 (6),756-777.Preview: Kinase Networks Regulate Metabolism: I'D(H1) Never Have Guessed!Sarah Horton and Brian J.P. Huntly (2019) Cancer Discovery DOI: 10.1158/2159-8290.CD- 19-0373.

11.Chen, P. H.; Cai, L.; Huffman, K.; Yang, C.; Kim, J.; Faubert, B.; Boroughs, L.; Ko, B.; Sudderth, J.; McMillan, E. A.; Girard, L.; Chen, D.; Peyton, M.; Shields, M. D.; Yao, B.; Shames, D. S.; Kim, H. S.; Timmons, B.; Sekine, I.; Britt, R.; Weber, S.; Byers, L. A.; Heymach, J. V.; Chen, J.; White, M. A.; Minna, J. D.; Xiao, G.; DeBerardinis, R. J., Metabolic Diversity in  Human  Non-Small  Cell  Lung  Cancer  Cells.Mol Cell2019,76 (5), 838-851 e5.

12.Gao, X.; Zhao, L.; Liu, S.; Li, Y.; Xia, S.; Chen, D.; Wang, M.; Wu, S.; Dai, Q.; Vu, H.; Zacharias, L.; DeBerardinis, R.; Lim, E.; Metallo, C.; Boggon, T. J.; Lonial, S.; Lin, R.; Mao, H.; Pan, Y.; Shan, C.; Chen, J., gamma-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Mol Cell 2019,76 (6), 857-871e9.

13.Chen, D.; Xia, S.; Zhang, R.; Li, Y.; Famulare, C.; Fan, H.; Wu, R,; Wang, M.; Zhu, A.; Elf, S.; Su, R.; Dong, L.; Arellano, M.; Blum, W.; Mao, H., Lonial, S.; Stock, W.; Odenike, O.; LeBeau, M.; Boggon, T.; He, C.; Chen, J.J.; Gao, X.; Levine, R. L.; Chen, J., Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. Mol Cell2021, 81, 3833–3847.

14.Zhang, R^#., Chen, D^#.; Fan,H.; Wu, R.; Li, Y.; Tu,J.;Zhang,F.; Wang,M,; Qu, C.; Elf,S.;Faubert, B.; Xue, G.; DeBerardinis, R.; Chen, J., Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation. Cell Chem Biol 2022， 29， 1200-1208.